发明名称 |
Hybrid peptides modulate the immune response |
摘要 |
The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.
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申请公布号 |
US2007178094(A1) |
申请公布日期 |
2007.08.02 |
申请号 |
US20070732639 |
申请日期 |
2007.04.04 |
申请人 |
HUMPHREYS ROBERT E;ADAMS SHARLENE;XU MINZHEN |
发明人 |
HUMPHREYS ROBERT E.;ADAMS SHARLENE;XU MINZHEN |
分类号 |
A61K39/395;C12Q1/02;A61K38/00;A61K39/00;A61K45/00;A61K47/48;A61P31/04;A61P35/00;A61P37/06;A61P37/08;C07K7/64;C07K14/74;C07K16/28;C07K19/00;C12P21/04;C40B30/06;C40B40/10;G01N33/50;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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