| 发明名称 |
Stabilized single domain antibodies |
| 摘要 |
The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
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| 申请公布号 |
US2007178082(A1) |
申请公布日期 |
2007.08.02 |
| 申请号 |
US20030534349 |
申请日期 |
2003.11.07 |
| 申请人 |
ABLYNX N.V. |
发明人 |
SILENCE KAREN;LAUWEREYS MARC;DREIER TORSTEN |
| 分类号 |
A61K48/00;A61K39/395;A61P11/06;A61P19/02;A61P31/06;A61P31/16;A61P35/00;A61P37/06;C07H21/04;C07K16/10;C07K16/12;C07K16/18;C07K16/24;C07K16/28;C07K16/30;C07K16/36;C07K16/40;C07K16/42;C07K16/46;C12N15/13;C12P21/06;G01N33/577 |
主分类号 |
A61K48/00 |
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