NOVEL HETEROCYCLIC NF-?B INHIBITORS

摘要

The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, Formula (III) wherein R³ is H, -C(O)NR^aR^b, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NR^4' OR^5' , NH₂, amine, alkylamine, alkoxy, cycloalkyl, heterocyclo-alkyl,hydroxyalkyl, or haloalkyloxy; R⁴ is H, halogen, alkyl, -C(NR⁷)NR^7'R⁸, -(CH₂)_paryl, -(CH₂)_PNR⁷R⁸, -C(O)NR⁷R⁸, -N=CR⁷R⁸, -NR⁷C(O)R⁸, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl; R⁵ is halogen, alkyl, -C(NR⁷)NR^7'R⁸, -(CH₂)_paryl, -(CH₂)_PNR⁷R⁸, -C(O)NR⁷R⁸, -N=CR⁷R⁸, -NR⁷C(O)R⁸, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl.