发明名称 |
AQUEOUS OPHTHALMIC SUSPENSION OF CRYSTALLINE REBAMIPIDE |
摘要 |
The invention provides an ophthalmic product containing rebamipide, which has a transparency enough to be agreeable feeling on using it and has neutral to weakly acidic pH not to injury of the keratoconjunctiva of a patient suffering from dry eye. An aqueous suspension of crystalline rebamipide which has an improved transparency is provided by adding an aqueous solution of rebamipide dissolved by a base such as sodium hydroxide or an aqueous solution of a salt of rebamipide to an aqueous acidic solution such as hydrochloric acid containing at least one of the compounds selected from water-soluble polymers and surfactants, and mixing them. |
申请公布号 |
EP1812000(A1) |
申请公布日期 |
2007.08.01 |
申请号 |
EP20050806737 |
申请日期 |
2005.11.11 |
申请人 |
OTSUKA PHARMACEUTICAL COMPANY, LIMITED |
发明人 |
MATSUDA, TAKAKUNI;HIRAOKA, SHOGO;TOMOHIRA, YUSO;ISHIKAWA, SHINICHI |
分类号 |
A61K31/4704;A61K9/08;A61K9/10;A61K47/32;A61K47/34;A61K47/38;A61P27/02 |
主分类号 |
A61K31/4704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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