发明名称 |
Method of inducing memory B cell development and terminal differentiation |
摘要 |
The invention provides a method for promoting differentiation of a mature naïve B cell or a B cell progenitor into a memory B cell or a plasma cell. The method comprises (a) contacting a population of cells comprising a mature naïve B cell or a B cell progenitor with an agent that activates at least one of JAK1, JAK3, STAT3, STAT5A or STAT5B; wherein the population of cells optionally is contacted with an antigen, and (b) isolating the memory B cell or plasma cell. |
申请公布号 |
GB2422845(B) |
申请公布日期 |
2007.08.01 |
申请号 |
GB20060009952 |
申请日期 |
2004.11.18 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMANSERVICES |
发明人 |
WARREN J LEONARD;PETER LIPSKI;HERBERT C MORSE III;CATHERINE RACHEL ETTINGER;ROSANNE SPOLSKI |
分类号 |
A61K35/12;A61K38/20;A61P37/06;C12N5/0781;G01N33/50 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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