Controlled release preparation

摘要

Disclosed is a capsule comprising: (i) a tablet, granule or fine granule in which the release of active ingredient is controlled comprising a core particle containing an imidazole compound represented by the formula (I') as defined in the specification, and a pH-dependently soluble release-controlled coating-layer which comprises one kind of polymeric substance or a mixture of two or more kinds of polymeric substances having different release properties, said substance being soluble in the pH range of 6.0 to 7.5; and (ii) a tablet, granule or fine granule comprising a core particle containing the active ingredient as defined above and an enteric coat which is dissolved in the pH range of no less than 5.0, nor more than 6.0.