发明名称 |
Inhibitors of n ethymalemide sensitive factor |
摘要 |
Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.
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申请公布号 |
US2007173441(A1) |
申请公布日期 |
2007.07.26 |
申请号 |
US20040553686 |
申请日期 |
2004.04.15 |
申请人 |
LOWENSTEIN CHARLES;MATSUSHITA KENJI;MORRELL CRAIG |
发明人 |
LOWENSTEIN CHARLES;MATSUSHITA KENJI;MORRELL CRAIG |
分类号 |
A61K38/17;A61K;C07K14/47;C07K14/705;C12P21/04 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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