发明名称 |
UNSOLVATED AND HOST-GUEST SOLVATED CRYSTALLINE FORMS OF (2E,4S)-4-[(N-{[(2R)-1-ISOPROPYLPIPERIDIN-2-YL]-CARBONYL}-3-METHYL-L-VALYL)(METHYL)AMINO]-2,5-DIMETHYLHEX-2-ENOIC ACID AND THEIR PHARMACEUTICAL USES |
摘要 |
The invention relates to unsolvated and host-guest solvated crystalline forms of (2E,4S)-4-[(N-{[(2R)-l-isopropylpiperidin-2-yl]- carbonyl}-3-methyl -L-valyl) (methyl)amino]-2,5-dimethylhex-2-enoic acid, E7974, and their therapeutic uses. Pharmaceutical compositions containing crystalline forms of E7974 and a pharmaceuticall acceptable carrier represent one embodiment of the invention. The invention also relates t methods for treating cancer, an inflammatory disorder, an autoimmune disorder, or a proliferative disorder as well as restenosis of blood vessels comprising the step of administering to a patient in need thereof a therapeutically effective amount of crystalline E7974. |
申请公布号 |
WO2006121857(A3) |
申请公布日期 |
2007.07.26 |
申请号 |
WO2006US17408 |
申请日期 |
2006.05.05 |
申请人 |
EISAI CO., LTD.;CAMPAGNA, SILVIO;POP, MIHAELA, MARIA |
发明人 |
CAMPAGNA, SILVIO;POP, MIHAELA, MARIA |
分类号 |
A61K31/445;C07D211/60 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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