发明名称 |
Codon optimi zed IL- 15 and IL- 15R-alpha genes for expression in mammalian cells |
摘要 |
The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-15 sequence. The present invention further provides expression vectors, and IL-15 and IL 15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human). |
申请公布号 |
AU2007207785(A1) |
申请公布日期 |
2007.07.26 |
申请号 |
AU20070207785 |
申请日期 |
2007.01.12 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH |
发明人 |
GEORGE N. PAVLAKIS;BARBARA K. FELBER |
分类号 |
C07K14/43 |
主分类号 |
C07K14/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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