| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound useful as a nitrogen monoxide production enhancer and/or endothelial nitrogen monoxide synthetase activator. SOLUTION: The nicotinamide derivative used as an active component of the medicine has blood circulation improving action based on excellent vascular endothelial nitrogen monoxide production enhancing action and/or endothelial nitrogen monoxide synthetase activating action. The medicine is useful as an agent for ameliorating diseases or pathological states caused by vascular endothelial function insufficiency, especially as a treating agent for peripheral artery obstruction, arteriosclerosis, ischemic heart disease, etc. It is useful also as a preventing or treating agent for dementia and an agent for the enhancement and/or promotion of the functional disorder recovery enhancing action or functional recovery exercising effect including the motility disorder caused by central neurodegeneration diseases such as cerebral apoplexy, brain injury and spinal cord injury. COPYRIGHT: (C)2007,JPO&INPIT
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