| 摘要 |
<p>A drug eluting stent for release over time of a detergent in loco at the site of an angioplasty procedure for the dissolution of the fatty component of the atherosclerotic plaque. The detergent has the capability of passing thru the fibrous cap and of targeting the fatty components of the plaque. The detergent is aimed at dissolving the cholesterol aggregates of the plaque post angioplasty procedure, plaque which is fractured, compressed, locally redistributed by the angioplasty procedure but that it is still present within the artery wall post angioplasty procedure. Numerous other pharmacological compounds with different targeted functions can be combined with the detergent in the stent including Antineoplastics, Immnunosuppressants, Migration inhibitors, Enhanced Healing Factors, Collagen and Proteoglycan degrading enzymes. The drug eluting stent by providing the dissolution of one of the major plaque components i.e. the fatty component is expected to greatly reduce the chance of restenosis.</p> |
