GEL-FORMING COMPOSITION FOR MEDICAL USE, DEVICES FOR THE APPLICATION OF THE COMPOSITION, AND DRUG RELEASE CONTROLLING CARRIER

摘要

The invention provides a gel-forming composition which permits on-site administration and can form a gel exhibiting a prescribed strength and sustained drug release, devices for the application thereof, and kits for medical use. A gel-forming composition which is composed of the first composition comprising a drug, the first gelling agent consisting of a compound of the general formula (I) and so on, and the first diluent and the second composition comprising the second gelling agent consisting of a compound of the general formula (I) and so on and the second diluent; and application devices and kits for medical use, which can hold the gel-forming composition: X<SUB>1</SUB>-(OCH<SUB>2</SUB>CH<SUB>2</SUB>)<SUB>n</SUB>-X<SUB>2</SUB> (I) wherein X<SUB>1</SUB> and X<SUB>2</SUB> are each -R<SUP>1</SUP>COONHS (wherein R<SUP>1</SUP> is C<SUB>1-7</SUB> alkylene), -COR<SUP>1</SUP>COONHS, -NOCOR<SUP>1</SUP>-R<SUP>2</SUP> (wherein R<SUP>2</SUP> is maleimido), -R<SUP>1</SUP>NH<SUB>2, </SUB>-R<SUP>1</SUP>SH, or -CO<SUB>2</SUB>PhNO<SUB>2</SUB>; and n is an integer of 80 to 1000.