WATER CHANNEL BLOCKERS AND METHODS OF USE THEREOF

摘要

The present invention provides a method of blocking water channels (such as aquaporins) in a subject in need thereof, comprising administering to said subject an active compound to block water channels in said subject, as well as the use of an active compound for the preparation of a medicament for blocking water channels in a subject in need thereof. Active compounds include pyrazinoylguanidine compounds (e.g. amiloride, benzamil, phenamil) and pharmaceutically acceptable salts or prodrugs thereof.