| 摘要 |
The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A]<SUB>n</SUB> where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula X<SUB>n</SUB>RXPX<SUB>3n</SUB> where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed. |
| 申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;DELMAR, MARIO;TAFFET, STEVEN, M. |
发明人 |
DELMAR, MARIO;TAFFET, STEVEN, M. |
