IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4ß, 8)-EPICATECHIN OR -CATEC

摘要

Improved processes for the preparation of tetra-O-benzyl protected -(+)-catechin, for the coupling of the tetra-O-benzyl protected -(+)-catechin or -(-)-epicatechin with a C-4 activated, tetra-O-benzyl protected -(-)-epicatechin, for the galloylation of the (-)-epicatechin-(4ß,8)-(+)-catechin or -(-)-epicatechin dimer to the dimer digallates, and for the deprotection (i.e., debenzylation) of the protected -(-)-epicatechin dimers and protected -(-)-epicatechin dimer digallates are disclosed.