INHIBITORS OF CANCER CELL, T-CELL AND KERATINOCYTE PROLIFERATION

摘要

The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is -NR^aR^b, -NR^cC=ONR^aR^b' -NR^cC=SNR^aR^b, -NR^cC=NR^dN^aR^b, heterocycle, - C=ONR^aR^b, heterocycle, or aryl; n is O to 8; m is 0, or 1 ; r is 0 to 3; t is O to 3; X is O or N; Z is CH₂, C=O, C=S or a single bond; Z¹ is CO-R², CS-R², (CH₂)_t-R² or the side-chain of a naturally occuring amino acid; , Z² is CO-R² , CS-R² or (CH₂)_t-R³ or the side-chain of a naturally occuring amino acid; Z³ is CO-R², CS-R² or (CH₂)_t-R⁴ or the side-chain of a naturally occuring amino acid; Z⁴ is H, alkyl, alkoxy, or cycloalkyl; R¹, R², R³, and R⁴ are independently from each other H, OH, SH, NH₂, CN, NO₂, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylarnino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen.