发明名称 |
GAT2 TRANSPORTERS EXPRESSED IN BLOOD BRAIN BARRIER CELLS |
摘要 |
GAT2 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the GAT2 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases. |
申请公布号 |
WO2007016159(A3) |
申请公布日期 |
2007.07.26 |
申请号 |
WO2006US29033 |
申请日期 |
2006.07.25 |
申请人 |
XENOPORT, INC.;ZERANGUE, NOA |
发明人 |
ZERANGUE, NOA |
分类号 |
G01N33/68;A61K38/00;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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