METHODS AND COMPOSITIONS FOR IN VITRO AND IN VIVO USE OF PARALLEL STRANDED HAIRPINS AND TRIPLEX STRUCTURES AS NUCLEIC ACID LIGANDS
摘要
The invention sets forth parallel-stranded hairpins and parallel-stranded hairpins carrying a single strand target, the parallel-stranded hairpins containing 8-aminopurine residues and are able to bind a target molecule of interest due to specificity in the two-dimensional and three-dimensional structures of the parallel-stranded hairpins and parallel-stranded hairpins carrying a single strand target. The invention also relates to creation of a library of parallel-stranded hairpins and associated triplexes for use as aptamers, as well as methods of synthesis of parallel-stranded hairpins and use of the structures of the invention to detect and eliminate molecules of interest.
申请公布号
WO2005067437(A3)
申请公布日期
2007.07.26
申请号
WO2004US25322
申请日期
2004.08.04
申请人
CYGENE, INC.;LOPEZ, MARTIN, J.;ERITJA, RAMON;MUNZER, MARTIN