发明名称 |
METHODS FOR GENERATING ANTIGEN-SPECIFIC EFFECTOR T CELLS |
摘要 |
The invention relates to T cells transiently transfected with RNA, especially RNA encoding a T cell receptor and/or FoxP3, and to methods of transfecting T cells with RNA by electroporation. Compositions of the invention include an effector T cell transiently transfected with RNA encoding a T cell receptor (TCR) specific for an antigen, wherein the T cell demonstrates effector function specific for cells presenting the antigen in complex with an MHC molecule. T<SUB>reg</SUB> cells comprising an exogenous RNA encoding FoxP3 are also provided. The transfected T cells are useful for immunotherapy, particularly in the treatment of tumors, pathogen infection, autoimmune disease, transplant rejection and graft versus host disease. |
申请公布号 |
WO2007065957(A3) |
申请公布日期 |
2007.07.26 |
申请号 |
WO2006EP69549 |
申请日期 |
2006.12.11 |
申请人 |
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN;SCHAFT, NIELS;SCHULER, GEROLD;DOERRIE, JAN |
发明人 |
SCHULER, GEROLD;DOERRIE, JAN |
分类号 |
C12N15/82;A61K39/00;C07K14/705;C12N5/0783 |
主分类号 |
C12N15/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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