Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell or a molecule with a sirtuin inhibitory compound that decreases the activity of a sirtuin and thereby reduces the life span of a cell, kills the cell or renders it suspectible to certain cell stresses including radiation and chemotherapy. Other methods include treating pathogens expressing a sirtuin.
申请公布号
WO2007084162(A2)
申请公布日期
2007.07.26
申请号
WO2006US12795
申请日期
2006.04.06
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;SINCLAIR, DAVID, A.;MAI, ANTONELLO