The present invention includes the use of at least one agent which induces endoplasmic reticulum (ER) stress together with at least one agent which gives rise to inhibition of protein disulfide isomerase (PDI) or GRP78 function for the preparation of a medicament, more particularly a medicament for the treatment of cancer, and to pharmaceutical compositions comprising an effective amount of at least one agent which induces ER stress together with at least one agent which gives rise to inhibition of PDI or GRP78 function, and which together provide a therapeutic effect.
申请公布号
WO2007083101(A2)
申请公布日期
2007.07.26
申请号
WO2007GB00125
申请日期
2007.01.17
申请人
CANCER RESEARCH TECHNOLOGY LIMITED;BIRCH-MACHIN, MARK;LOVAT, PENNY;REDFERN, CHRISTOPHER
发明人
BIRCH-MACHIN, MARK;LOVAT, PENNY;REDFERN, CHRISTOPHER