3-ARYLOXY UND 3-HETEROARYLOXY SUBSTITUIERTE BENZO(B) THIOPHENE ALS THERAPEUTISCHE WIRKSTOFFE MIT PI3K AKTIVITÄT

摘要

The present invention provides benzo[b]thiophenes of Formula I: wherein R<1>, R<2>, R<3>, R<4>, R<5>, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.