| 摘要 |
The present invention provides synthetic CXCR3 ligands, including consensus CXCR3 ligands and hybrid CXCR3 ligands; and compositions comprising the ligands. The present invention provides polynucleotides encoding the synthetic CXCR3 ligands; expression vectors comprising the polynucleotides; and host cells comprising the polynucleotidess. The present invention provides methods of treating fibrotic disorders; methods of treating angiogenic disorders; methods of treating cancer; and methods of treating bacterial infections. The methods generally involve administering to an individual in need thereof an effective amount of a subject synthetic CXCR3 ligand. <tables id="TABLE-US-00001" num="1"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="1" colwidth="217PT" align="right"/> <colspec colname="2" colwidth="0PT" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> <ROW> <ENTRY>(SEQ ID NO: 15)</ENTRY> <ENTRY/> </ROW> </TBODY> </TGROUP> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="1" colwidth="217PT" align="left"/> <colspec colname="2" colwidth="0PT" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY>MKKSGVLFLLGIILLVLIGVQGFPMFKRGRCLCIGPGVKPVNPRSLEKLE</ENTRY> <ENTRY/> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY>IIPASQFCPRIEIIATLKNGVQTCLNPDSKQARLIIKKVSKEMSKRSP</ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES>
|
