发明名称 |
CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF NA(+) CL(-)-DEPENDENT NEUROTRANSMITTER TRANSPORTERS |
摘要 |
<p>The present invention relates to three dimensional structural models of the LeuT<SUB>Aa</SUB> transporter, and, in particular, the modeled sites of these proteins. The structural information of the present invention may be used for the rational design of compounds which act as modulators of the LeuT<SUB>Aa</SUB> transporter and its eukaryotic counterparts. The present invention further provides for actual or virtual screening assays which may be used to identify compounds having such modulator activities, or to confirm the activity of designed compounds.</p> |
申请公布号 |
WO2007084133(A1) |
申请公布日期 |
2007.07.26 |
申请号 |
WO2006US02187 |
申请日期 |
2006.01.23 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;GOUAUX, JAMES;YAMASHITA, ATSUKO |
发明人 |
GOUAUX, JAMES;YAMASHITA, ATSUKO |
分类号 |
G06F15/00;C07K14/00;G06G7/58 |
主分类号 |
G06F15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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