发明名称 |
ANTICOAGULANT FUSION PROTEIN ANCHORED TO CELL MEMBRANE |
摘要 |
<p>The invention relates to the inhibition of blood coagulation, especially during organ rejection, and in particular the inhibition of delayed vascular rejection.</p><p>The invention provides anticoagulant proteins which are anchored to cell membranes. The anticoagulant function is preferably provided by heparin, antithrombin, hirudin, TFPI, tick anticoagulant peptide, or a snake venom factor.</p><p>These anticoagulant proteins are preferably prevented from being constitutively expressed at the cell surface. In particular, expression at the cell-surface is regulated according to cell-activation, for instance by targeting the protein to a suitable secretory granule.</p><p>Expression of these proteins renders cells, tissues and organs less vulnerable to rejection after transplantation (eg. after xenotransplantation).</p> |
申请公布号 |
EP1676920(A3) |
申请公布日期 |
2007.07.25 |
申请号 |
EP20050077712 |
申请日期 |
1998.03.26 |
申请人 |
IMPERIAL INNOVATIONS LIMITED |
发明人 |
RIESBECK, KRISTIAN;DORLING, ANTHONY;GEORGE, ANDREW JOHN TIMOTHY;LECHLER, ROBERT JAN |
分类号 |
A01K67/027;C12N15/62;A61K38/00;A61K48/00;A61P7/02;A61P37/06;C07K14/705;C07K14/73;C07K14/74;C07K14/81;C07K14/815;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/00;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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