POLYNUCLEOTIDE FOR PRODUCTION OF RECOMBINANT PROTEIN BY SILKWORM

摘要

As a novel means capable of secreting a recombinant protein produced in silkworm middle silk gland into a cocoon and extracting the recombinant protein easily without denaturing the steric structure of the protein, there is provided a polynucleotide functionally linked to a recombinant protein structural gene in an expression cassette for expressing the recombinant protein in silkworm middle silk gland, wherein a polynucleotide constituting a promoter region of sericin 1 or sericin 2 gene and a polynucleotide constituting baculovirus homologous regions are functionally linked.