发明名称 |
METHODS FOR INCREASING THE DIVERSITY OF MONOCLONAL ANTIBODIES PRODUCED AGAINST AN ANTIGEN |
摘要 |
<p>The present invention relates to methods for increasing the diversity of monoclonal antibodies produced against an antigen. The methods of the invention utilize immunization of a murine host defective in one or more enzymes involved in a post-translational modification of a polypeptide or a modification of a lipid, wherein said modification is exposed on a cell surface. The invention also relates to monoclonal antibodies produced by these methods and which are not produced when a normal mouse is immunized with the same antigen. The invention further relates to compositions comprising these monoclonal antibodies, as well as to such monoclonal antibodies bound or conjugated to a toxin, a detectable marker or to a solid support.</p> |
申请公布号 |
EP1809098(A1) |
申请公布日期 |
2007.07.25 |
申请号 |
EP20050803940 |
申请日期 |
2005.10.12 |
申请人 |
TRANSLATIONAL MEDICINES, INC. |
发明人 |
CUMMING, DALE ANTHONY |
分类号 |
A01K67/027;A61K38/00;A61K39/00;C07K16/10;C07K16/18;C07K16/28;C07K16/30;C12N9/10 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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