| 发明名称 | α结晶形式的哌林多普利叔丁基胺盐 | ||
| 摘要 | 本发明涉及α结晶形式的式(I)化合物，其特征在于其粉末X射线衍射图案。本发明可用于制备药物。∴ | ||
| 申请公布号 | CN1328259C | 申请公布日期 | 2007.07.25 |
| 申请号 | CN01812354.6 | 申请日期 | 2001.07.06 |
| 申请人 | 瑟维尔实验室 | 发明人 | B·普法伊费尔;Y－M·吉诺;G·科克雷尔;S·贝耶 |
| 分类号 | C07D209/42(2006.01);A61K31/475(2006.01);A61P9/12(2006.01) | 主分类号 | C07D209/42(2006.01) |
| 代理机构 | 北京市中咨律师事务所 | 代理人 | 刘金辉;林柏楠 |
| 主权项 | 1.α结晶形式的式(I)化合物：<img file="C018123540002C1.GIF" wi="955" he="576" />其特征在于其具有使用衍射仪(铜对阴极)测量并以晶面间距d、布拉格角2θ、强度和相对强度(以相对于最强射线的百分数表达)表达的以下粉末X射线衍射图：<tables id="table1" num="001"><table width="819"><tgroup cols="4"><colspec colname="c001" colwidth="23%" /><colspec colname="c002" colwidth="27%" /><colspec colname="c003" colwidth="19%" /><colspec colname="c004" colwidth="30%" /><thead><row><entry morerows="1"> 2θ角(°)</entry><entry morerows="1"> 晶面间距d(_)</entry><entry morerows="1"> 强度</entry><entry morerows="1"> 相对强度(％)</entry></row></thead><tbody><row><entry morerows="1"> 7.680</entry><entry morerows="1"> 11.50</entry><entry morerows="1"> 390</entry><entry morerows="1"> 8.8</entry></row><row><entry morerows="1"> 8.144</entry><entry morerows="1"> 10.85</entry><entry morerows="1"> 230</entry><entry morerows="1"> 5.2</entry></row><row><entry morerows="1"> 9.037</entry><entry morerows="1"> 9.78</entry><entry morerows="1"> 4410</entry><entry morerows="1"> 100</entry></row><row><entry morerows="1"> 10.947</entry><entry morerows="1"> 8.08</entry><entry morerows="1"> 182</entry><entry morerows="1"> 4.1</entry></row><row><entry morerows="1"> 13.150</entry><entry morerows="1"> 6.73</entry><entry morerows="1"> 82</entry><entry morerows="1"> 1.9</entry></row><row><entry morerows="1"> 13.687</entry><entry morerows="1"> 6.46</entry><entry morerows="1"> 83</entry><entry morerows="1"> 1.9</entry></row><row><entry morerows="1"> 14.627</entry><entry morerows="1"> 6.05</entry><entry morerows="1"> 582</entry><entry morerows="1"> 13.2</entry></row><row><entry morerows="1"> 15.412</entry><entry morerows="1"> 5.74</entry><entry morerows="1"> 770</entry><entry morerows="1"> 17.5</entry></row><row><entry morerows="1"> 16.573</entry><entry morerows="1"> 5.34</entry><entry morerows="1"> 1115</entry><entry morerows="1"> 25.3</entry></row><row><entry morerows="1"> 17.357</entry><entry morerows="1"> 5.10</entry><entry morerows="1"> 340</entry><entry morerows="1"> 7.7</entry></row><row><entry morerows="1"> 18.109</entry><entry morerows="1"> 4.89</entry><entry morerows="1"> 193</entry><entry morerows="1"> 4.4</entry></row><row><entry morerows="1"> 19.922</entry><entry morerows="1"> 4.45</entry><entry morerows="1"> 306</entry><entry morerows="1"> 6.9</entry></row><row><entry morerows="1"> 20.609</entry><entry morerows="1"> 4.31</entry><entry morerows="1"> 375</entry><entry morerows="1"> 8.5</entry></row><row><entry morerows="1"> 21.412</entry><entry morerows="1"> 4.15</entry><entry morerows="1"> 226</entry><entry morerows="1"> 5.1</entry></row><row><entry morerows="1"> 21.832</entry><entry morerows="1"> 4.07</entry><entry morerows="1"> 217</entry><entry morerows="1"> 4.9</entry></row><row><entry morerows="1"> 22.158</entry><entry morerows="1"> 4.01</entry><entry morerows="1"> 483</entry><entry morerows="1"> 11</entry></row><row><entry morerows="1"> 22.588</entry><entry morerows="1"> 3.93</entry><entry morerows="1"> 386</entry><entry morerows="1"> 8.8</entry></row><row><entry morerows="1"> 23.323</entry><entry morerows="1"> 3.81</entry><entry morerows="1"> 107</entry><entry morerows="1"> 2.4</entry></row><row><entry morerows="1"> 24.200</entry><entry morerows="1"> 3.67</entry><entry morerows="1"> 448</entry><entry morerows="1"> 10.2</entry></row><row><entry morerows="1"> 24.727</entry><entry morerows="1"> 3.60</entry><entry morerows="1"> 137</entry><entry morerows="1"> 3.1</entry></row><row><entry morerows="1"> 25.957</entry><entry morerows="1"> 3.43</entry><entry morerows="1"> 125</entry><entry morerows="1"> 2.8</entry></row><row><entry morerows="1"> 26.932</entry><entry morerows="1"> 3.31</entry><entry morerows="1"> 75</entry><entry morerows="1"> 1.7</entry></row></tbody></tgroup></table></tables><tables id="table2" num="002"><table width="806"><tgroup cols="4"><colspec colname="c001" colwidth="24%" /><colspec colname="c002" colwidth="27%" /><colspec colname="c003" colwidth="19%" /><colspec colname="c004" colwidth="29%" /><thead><row><entry morerows="1"> 27.836</entry><entry morerows="1"> 3.20</entry><entry morerows="1"> 197</entry><entry morerows="1"> 4.5</entry></row></thead><tbody><row><entry morerows="1"> 28.966</entry><entry morerows="1"> 3.08</entry><entry morerows="1"> 129</entry><entry morerows="1"> 2.9</entry></row><row><entry morerows="1"> 29.213</entry><entry morerows="1"> 3.05</entry><entry morerows="1"> 117</entry><entry morerows="1"> 2.7</entry></row></tbody></tgroup></table></tables> | ||
| 地址 | 法国库伯瓦 | ||