Method for producing optically active compound

摘要

The present invention provides a method for producing an optically active beta-hydroxy ester compound represented by the general formula: wherein R¹ represents an optionally substituted hydrocarbon group and the like, R² represents a nitrogen-containing heterocyclic group different from R¹, which is represented by the general formula: wherein the ring may be substituted and the like, R³ represents an optionally substituted hydrocarbon group and the like, R⁴ and R⁵ represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol "*" represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R¹ and R² are as defined above with a compound represented by the general formula: wherein R³, R⁴ and R⁵ are as defined above, and X is a halogen atom.