发明名称 |
Use of DF3/MUC1 regulated expression in gene therapy |
摘要 |
The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tumor cells. In addition, therapeutic genes and adjunct therapies further increase anti-tumor efficacy.
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申请公布号 |
US7247297(B2) |
申请公布日期 |
2007.07.24 |
申请号 |
US20020244705 |
申请日期 |
2002.09.16 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
WEICHSELBAUM RALPH R.;KUFE DONALD W. |
分类号 |
A61K48/00;A01N63/00;A61K38/19;C12N15/861 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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