TETRALIN AND INDANE DERIVATIVES AND USES THEREOF.

摘要

Compounds of the formula (I), or pharmaceutically acceptable salts thereof,wherein R2 is (CR3R4)n-NR5R6and m, p, q, Ar, R1, R3, R4, R5 and R6are as defined in the claims, which are selective antagonists of 5-HT6and/or 5-HT2A. Also provided are compositions comprising these compoundsand their use in the preparation of medicaments for treating central nervoussystem disease states selected from psychoses, schizophrenia, manic depressions,neurological disorders, memory disorders, attention deficit disorder, Parkinson sdisease, amyotrophic lateral scierosis, Alzheimer s disease, fooduptake disorders and Huntington s disease.