| 摘要 |
A chiral compound is described, in racemic, (R)- or (S)- form, which is a 2-(2,6-dioxo-3-fluoropiperidin-3-yl)- isoindoline of the formula: (see formula I) in which Y is oxygen or H2 and each of R1, R2, R3, and R4, independently of the others, is hydrogen, halo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or amino, or the acid addition salts of said 2-(2,6-dioxo-3- fluoropiperidin-3-yl)-isoindolines which contain a nitrogen atom capable of being protonated. 1-Oxo-2-(2,6-dioxo-3- fluoropiperidin-3-yl)-isoindolines and 1,3-dioxo-2-(2,6- dioxo-3-fluoropiperidin-3-yl)-isoindolines reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3--fluoropiperidin-3-yl)- isoindoline. |
