| 摘要 |
FIELD: medicine, biochemistry. ^ SUBSTANCE: invention relates to a method for identifying epitopes of T-cells that induce the immune response in living organism-host. By this method immunogenicity-free biological compounds can be prepared or with reduced immunogenicity and in comparison with the corresponding unmodified object by decreasing or removing potential epitopes of T cells in limits of sequence of the parent immunogenic molecules. Also, invention relates to novel biological molecules being especially to proteins and antibodies prepared by the proposed invention. Invention provides reducing immunogenicity of biological compounds. ^ EFFECT: improved identifying method. ^ 17 cl, 3 tbl, 8 dwg, 22 ex |
