| 发明名称 |
POLYNUCLEOTIDE ENCODING MACROPHAGE INFLAMMATORY PROTEIN VARIANTS |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain proteins which have stem cell inhibitory activity and do not significantly aggregate. <P>SOLUTION: Disclosed are polynucleotides which have stem cell inhibitory activity, contain a sequence of SEQ ID NO:2 from amino acid 28 to amino acid 93, have amino acid substitution selected from the following substitution: a. from 90(Glu) to 90(Gln); b. from 90(Glu) to 90(Gln) and from 88(Asp) to 88(Asn); and c. from 90(Glu) to 90(Gln), from 88(Asp) to 88(Asn) and from 84(Lys) to 84(Gln), and encode a protein which does not significantly aggregate. <P>COPYRIGHT: (C)2007,JPO&INPIT |
| 申请公布号 |
JP2007181465(A) |
申请公布日期 |
2007.07.19 |
| 申请号 |
JP20070029147 |
申请日期 |
2007.02.08 |
| 申请人 |
CANCER RESEARCH TECHNOLOGY LTD |
发明人 |
GRAHAM GERARD;PRAGNELL IAN |
| 分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/22;A61K48/00;A61P17/06;A61P35/00;A61P35/02;A61P39/00;A61P43/00;C07K14/47;C07K14/52;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/19;C12P21/02 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
