| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a protein complex-based binding reagent having high affinity, low mitogenic actions and high in vivo stability. <P>SOLUTION: The protein complex-based binding reagent comprises a triple-helix-coil forming a fusion polypeptide chain each having a scaffold domain and a heterologous domain. Furthermore, a related isolated fusion polypeptide, a nucleic acid, a vector and a host cell are provided and a method for producing the fusion polypeptide is provided. A method for culturing the host cell and purifying the protein complex is provided. The reagent may become even multi-valent or a multi-specific. <P>COPYRIGHT: (C)2007,JPO&INPIT |
