发明名称 |
NEW CHOLEST-4-EN-3-ONE OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND PREPARATION PROCESS |
摘要 |
<p>New and known 4-cholesten-3-one oxime derivatives (I) are used as medicaments. 4-Cholesten-3-one oxime derivatives of formula (I) and their acid addition salts are used as medicaments. X = O or NOH; R = (CH 2) 4CH(Me) 2, (CH 2) 3CH=C(Me) 2, (CH 2) 3CH(Et)CH(Me) 2, trans-CH 2CH=CHCH 2CH(Me) 2, trans-CH 2CH=CHCH(Et)CH(Me) 2 or trans-CH 2CH=CHCH(Me)CH(Me) 2. An independent claim is also included for new (I) other than 3-hydroxyimino-4-cholesten-6-one and 4-cholestene-3,6-dioxime. [Image] ACTIVITY : Neuroprotective. 3-Hydroxyimino-4-cholesten-6-one had a positive effect on the survival of bone-marrow motoneurons at a concentration of 3 mu M, as indicated by a ratio (not defined) of 0.6. MECHANISM OF ACTION : None given.</p> |
申请公布号 |
CA2633633(A1) |
申请公布日期 |
2007.07.19 |
申请号 |
CA20062633633 |
申请日期 |
2006.12.15 |
申请人 |
TROPHOS |
发明人 |
MAUX, DELPHINE;DROUOT, CYRILLE |
分类号 |
C07J41/00;A61K31/575;A61P25/00;A61P25/28 |
主分类号 |
C07J41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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