| 摘要 |
The invention provides a compound or its pharmaceutically-acceptable salt of formula wherein A<SUB>1 </SUB>is a hydrogen, etc.; j and k are 0 or 1; <img id="custom-character-00001" he="3.13mm" wi="9.14mm" file="US20070167453A1-20070719-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/> is a double bond, etc.; <img id="custom-character-00002" he="3.13mm" wi="9.48mm" file="US20070167453A1-20070719-P00002.TIF" alt="custom character" img-content="character" img-format="tif"/> is a double bond, etc.; one of W<SUB>1 </SUB>and W<SUB>2 </SUB>is E-O-W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
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