The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclosed. A number of the compounds possess submicromolar IC<SUB>50</SUB> and CC<SUB>50</SUB> values and have a selective toxicity for colon cancers and leukemic cells. In addition, many of the compounds are able to reverse multidrug resistance.
申请公布号
WO2007059613(B1)
申请公布日期
2007.07.19
申请号
WO2006CA01908
申请日期
2006.11.22
申请人
UNIVERSITY OF SASKATCHEWAN;DIMMOCK, JONATHAN R.;DAS, UMASHANKAR
