发明名称 |
Methods for production of receptor and ligand isoforms |
摘要 |
Provided are methods for production of cell surface receptor (CSR) and ligand isoforms. In particular, isoform fusions that a precursor sequence for secretion, processing and intracellular trafficking are provided. Nucleic acid molecules encoding the fusions are expressed in a host cell and the encoded and partially or completely processed encoded CSR or ligand isoforms is produced in the cell culture medium. The resulting polypeptide optionally includes an epitope tag for the detection and/or purification thereof.
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申请公布号 |
US2007166788(A1) |
申请公布日期 |
2007.07.19 |
申请号 |
US20060591229 |
申请日期 |
2006.10.31 |
申请人 |
JIN PEI;SHEPARD H M;GORMAN CORNELIA M;ZHANG JUAN |
发明人 |
JIN PEI;SHEPARD H. M.;GORMAN CORNELIA M.;ZHANG JUAN |
分类号 |
A61K48/00;C07H21/04;C12N5/06;C12N9/12;C12P21/06 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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