摘要 |
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B. |
申请人 |
MERCK & CO., INC.;ALI, AMJAD;LU, ZHIJIAN;SINCLAIR, PETER, J.;CHEN, YI-HENG;SMITH, CAMERON, J.;LI, HONG;THOMPSON, CHRISTOPHER, F. |
发明人 |
ALI, AMJAD;LU, ZHIJIAN;SINCLAIR, PETER, J.;CHEN, YI-HENG;SMITH, CAMERON, J.;LI, HONG;THOMPSON, CHRISTOPHER, F. |