摘要 |
<p>There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.</p> |
申请人 |
MALLINCKRODT INC.;MANNINO, ANTHONY;HOEFGEN, ERIK, R.;HILL, LLOYD, P.;BUEHLER, HENRY, J. |
发明人 |
MANNINO, ANTHONY;HOEFGEN, ERIK, R.;HILL, LLOYD, P.;BUEHLER, HENRY, J. |