发明名称 |
Process for preparing benzhydrylthioacetamide |
摘要 |
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The reaction employing the haloacetamide is conducted in a solvent comprising water and an organic solvent such as dimethylformamide having dissolved therein a basic salt such as potassium carbonate. The resulting benzhydrylthioacetamide can be oxidized to provide the pharmaceutical modafinil.
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申请公布号 |
US7244865(B2) |
申请公布日期 |
2007.07.17 |
申请号 |
US20050537965 |
申请日期 |
2005.06.09 |
申请人 |
MALLINCKRODT INC. |
发明人 |
LIANG SIDNEY |
分类号 |
C07C233/00;C07C315/02;C07C315/06;C07C317/44;C07C319/14;C07C319/20;C07C323/60;C07C335/32 |
主分类号 |
C07C233/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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