HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR.

摘要

The invention relates to compounds of the formula (I) wherein n is 0, 1 or 2; G isCH2 or CHR3; R1 is H, C,-C6-alkyl, C,-C6-alkylsubstituted by C3-C6-cycloalkyl, Cl-C6-hydroxyalkyl,fluorinated C,-C6-alkyl, C3-C6-cycloalkyl,fluorinated C3-C6-cycloalkyl, C3-C6 ialkenyl, fluorinated C3-C6-alkenyl, formyl, acetyl orpropionyl; R2, R3 and R4 are, independently ofeach other, H, methyl, fluoromethyl, difluoromethyl, or trifluoromethyl;A is phenylene, pyridylene, pyrimidylene, pyrazinylene, pyridazinylene orthiophenylene, which can be substituted by one ore more substituents selectedfrom halogen, methyl, methoxy and CF3; E is NR5 or CH2,wherein R5 is H or C1 -C3-alkyl; Ar is a cyclic radicalselected from the group consisting of phenyl, a 5- or 6- imembered heteroaromaticradical comprising as ring members 1, 2 or 3 heteroatoms selected from N, O andS and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclicor heterocyclic ring, where the heterocyclic ring comprises as r ing members1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containinggroups each independently selected from NR8, where R8 isH, C1-C4-alkyl, fluorinated C1-C4-alkyl,C1-C4 ialkylcarbonyl or fluorinated C1-C4-alkylcarbonyl,and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra, whereinthe variable Ra has the meanings given in the claims and in the description;and physiologically tolerated acid addition salts thereof. The invention alsorelates to the use of a compound of the formula I or a pharmaceutically acceptablesalt thereof for preparing a pharmaceutical composition for the treatment ofa medical disorder susceptible to treatment with a dopamine D3 receptor ligand.