发明名称 |
Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
摘要 |
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
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申请公布号 |
US7244412(B2) |
申请公布日期 |
2007.07.17 |
申请号 |
US20040853824 |
申请日期 |
2004.05.26 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
LIN HENRY C. |
分类号 |
A61K49/00;G01N27/62;A01N31/00;A23L1/29;A61K9/08;A61K9/10;A61K9/14;A61K9/22;A61K9/28;A61K9/48;A61K9/50;A61K31/201;A61K31/353;A61K31/4045;A61K31/496;A61K33/18;A61K33/24;A61K33/40;A61K35/00;A61K35/22;A61K35/23;A61K38/00;A61K38/17;A61K38/22;A61K39/00;A61K45/06;A61K51/12;A61P1/02;A61P1/04;A61P3/00;A61P19/08;A61P21/00;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P31/04;G01N30/62;G01N30/86;G01N30/88;G01N30/90;G01N33/497;G01N33/50;G01N33/68 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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