| 发明名称 |
Acetyl 2-hydroxy-1, 3-diaminoalkanes |
| 摘要 |
Disclosed are compounds of the formula: where variables Z, X, R<SUB>15</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, and R<SUB>C </SUB>are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
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| 申请公布号 |
US7244725(B2) |
申请公布日期 |
2007.07.17 |
| 申请号 |
US20030658959 |
申请日期 |
2003.09.10 |
| 申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
JOHN VARGHESE;MAILLARD MICHEL;BECK JAMES P.;BALDWIN ERIC T.;HUGHES ROBERT;PULLEY SHON R.;TENBRINK RUTH |
| 分类号 |
C07D279/04;A61K31/135;A61K31/16;A61K31/18;A61K31/35;A61K31/38;A61K31/40;A61K31/44;A61K31/54;C07C233/05;C07C233/36;C07C235/10;C07C235/74;C07C271/24;C07C311/05;C07C327/30;C07D213/38;C07D215/22;C07D215/233;C07D215/38;C07D215/42;C07D311/04;C07D311/74;C07D335/04;C07D335/06;C07D495/04 |
主分类号 |
C07D279/04 |
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