| 摘要 |
The present invention relates to tricyclic pyrrole derivatives of the general formula (see formula I) wherein R1 to R4 each signify hydrogen, halogen, lower alkyl, phenyl, cycloalkyl or lower alkoxy and R2 additionally signifies lower alkoxycarbonyl, acyloxy or mesyloxy; R5 to R7 each signify hydrogen or lower alkyl; X signifies -CH2CH(C6H5)-, -CH=C(C6H5)-, -YCH2-, -CH=CH- or -(CR11R12)n; R11 and R12 each signify hydrogen, phenyl, lower alkyl or halogen; n signifies 1 to 3 and Y signifies O or S, as well as pharmaceutically usable salts of basic compounds of formula I with acids. These compounds and salts are novel and are distinguished by valuable pharmacological properties. They can be used in the control or prevention of illnesses or in the improvement of health, especially in the control or prevention of central nervous disorders such as depressions, bipolar disorders, anxiety states, sleep and sexual disorders, psychoses, schizophrenia, migraine and other conditions associated with cephalic pain or pain of a different kind, personality disorders or obsessive-compulsive disorders, social phobias or panic states, mental organic disorders, mental disorders in childhood, aggressivity, age-related memory disorders and behavioural disorders, addiction, obesity, bulimia etc.; damages of the nervous system by trauma, stroke, neurodegenerative diseases etc.; cardiovascular disorders such as hypertension, thrombosis, stroke etc.; and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
|
