| 摘要 |
<p>R = H, Ac P = purine or pyrimidine residue, e.g. 1-thyminyl 1-uracilyl, 1-(5-halouracilyl), 1-cytidyl, 9-adenyl or 9-guanyl The cpds. are cytostatically active, e.g. against Ehrlich ascites tumour cells in vitro. 2'-Desoxyribonucleosides contg. 5'-arylsulphonyl or 5'-mesyl radicals, & opt. acetylated, are treated with an alkali fluoride for 15 min. -5 hr. (pref. 1/2-2 hr) in a solvent such as acetamide, dimethylacetamide, glycol or MeOH, at 50-160 deg. (pref. 130-150 deg.) & the product purified by chromatography.</p> |
