Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment

摘要

Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R¹ preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which C is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The prodrug is expected to be activated preferentially in tumour cells, which it will act as a DNA alkylating agent preventing cell division.