发明名称 |
Diagnostic and therapeutic use of the human sgpl1 gene and protein for neurodegenerative diseases |
摘要 |
The present invention discloses the differential expression of a gene coding for SGPL1 in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the SGPL1 gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
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申请公布号 |
US2007162983(A1) |
申请公布日期 |
2007.07.12 |
申请号 |
US20040595930 |
申请日期 |
2004.11.18 |
申请人 |
EVOTEC NEUROSCIENCES GMBH |
发明人 |
HESTERKAMP THOMAS;VON DER KAMMER HEINZ;POHLNER JOHANNES |
分类号 |
A01K67/027;C12N9/88;C12Q1/68;G01N33/53;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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