A pharmaceutical composition comprises (a) metronidazole in an antibacterially effective amount; and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
申请公布号
WO2007079389(A2)
申请公布日期
2007.07.12
申请号
WO2006US62652
申请日期
2006.12.28
申请人
DRUGTECH CORPORATION;LEVINSON, R., SAUL;BORTZ, JONATHAN;KIRSCHNER, MITCHELL;CUCA, ROBERT, C.
发明人
LEVINSON, R., SAUL;BORTZ, JONATHAN;KIRSCHNER, MITCHELL;CUCA, ROBERT, C.